Bovine Secondary Antibodies
Cayman Chemical ANTIBODY UCM53 500ug
An inhibitor of bacterial cell division; binds to the GTP site of the cell division protein FtsZ from B. subtilis in a fluorescent anisotropy assay; reduces the number of FtsZ rings and increases the number of foci in B. subtilis at 3 μM and induces filamentation at 12 μM; active against laboratory strains and clinical isolates of the Gram-positive bacteria B. subtilis, S. aureus, E. faecium, and E. faecalis (MICs = 2-8 mg/L) but is less effective against S. pneumoniae and the Gram-negative bacteria P. aeruginosa, E. coli, and K. pneumoniae (MICs = 32-128 mg/L); inhibits cell growth in a panel of cancerous (IC50s = 16.9-76.5 mg/L) and non-cancerous mammalian cell lines (IC50s = 23.5-93.9 mg/L)
Cayman Chemical ANTIBODY HPPD-Q 500ug
A substituted p-phenylenediamine quinone; a derivative of 6-PPD-Q; not toxic to rainbow trout (O. mykiss) at concentrations up to 50 UG/L for 96 hours
Cayman Chemical ANTIBODY LAS191859 500ug
A CRTH2/DP2 antagonist (IC50s = 9.58, 14, 15.5, and 7.6 nM for recombinant human, rat, mouse, and guinea pig CRTH2/DP2 receptors, respectively); selective for CRTH2/DP2 over a panel of 65 enzymes, ion channels, and transporters with 2-induced shape change of eosinophils (IC50s = 2 and 8.2 nM in isolated eosinophils and whole blood, respectively) and eosinophil chemotaxis (IC50 = 1.3 nM); reduces PGD2-induced systemic eosinophilia in guinea pigs (ID50 = 131 μg/kg)
Cayman Chemical ANTIBODY SetosusIn 500ug
A fungal metabolite; reduces Aβ aggregate-induced neurotoxicity in PC12 cells (EC50 = 112.6 μM); induces tremors in mice at 30 mg/kg
Cayman Chemical ANTIBODY a-Caroten 500ug
A precursor of vitamin A; inhibits proliferation of GOTO human neuroblastoma cells more potently than β-carotene; halts the cell cycle at the G0/G1 phase and reduces mRNA expression of the protooncogene N-Myc; decreases the number of hepatomas in mice with spontaneous liver carcinogenesis (0.05% in drinking water)
Cayman Chemical ANTIBODY 9 S-HpOTrE 500ug
9(S)-HpOTrE is a monohydroperoxy PUFA produced by the action of 5-LO on α-linolenic acid.{2226} It can be further metabolized to colnelenic acid by a divinyl ether synthase activity found in garlic and potato microsomal fractions.{6086,3824} 9(S)-HpOTrE also serves as a substrate for further oxidation by both soybean and potato LOs, resulting in the formation of 9,16-dihydroperoxy acid.{6085,6087} The suicide inactivation of LOs when 9(S)-HpOTrE is used as a substrate is thought to occur via formation of an unstable epoxide.{6083,6084}
Cayman Chemical ANTIBODY RY785 500ug
A selective inhibitor of Kv2.1 voltage-gated potassium channels (IC50 = 0.05 µM)
Cayman Chemical 13 S-HODE-bIotIn 500ug
13(S)-HODE is the LO metabolite of linoleic acid. 13(S)-HODE modulates the PAF, LTB4, and fMLP-induced calcium influx in human PMNL. The mechanism by which 13(S)-HODE elicits its inhibitory effect is still unclear. The use of biotinylated 15(S)-HETE as a probe for detecting binding proteins and/or receptors that specifically bind 15(S)-HETE provides a basis for similar use of 13(S)-HODE-biotin.
Cayman Chemical ANTIBODY BKT 140 500ug
A CXCR4 antagonist (IC50 = 0.91 nM); inhibits HIV-1-induced cytopathogenicity in MT-4 cells (EC50 = 4 nM); reduces CXCL12-induced migration of SUP-T1 leukemia and MDA-MB-231 at 100 nM; induces apoptosis in NB4 leukemia and RPMI-8226 multiple myeloma cancer cells at 8 and 40 µM; reduces pulmonary metastasis in an MDA-MB-231 mouse xenograft model; reduces the incidence of arthritis in a mouse model of collagen-induced arthritis
Cayman Chemical ANTIBODY Dth 500ug
A PROTAC that drives aptamer-defined protein degradation; composed of DFHBI and thalidomide; induces degradation of mCherry in HEK293T cells at 20 µM; induces degradation of p50, as well as p50 and E2F1, in MCF-7 cells at 20 µM
Cayman Chemical ANTIBODY UrodIlatIn 500ug
A renal natriuretic peptide that regulates sodium and water reabsorption in the kidney; has pharmacological effects on renal, cardiovascular, and pulmonary parameters in animals
Cayman Chemical ANTIBODY VER-50589 500ug
An isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM; produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel
Cayman Chemical ANTIBODY U-51605 500ug
A stable analog of PGH2 that inhibits both PGI and TX synthases with more selectivity towards PGI synthase; a partial agonist at TP receptors
Cayman Chemical ANTIBODY CZC-8004 500ug
An aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES
Cayman Chemical ANTIBODY OTS514 500ug
An inhibitor of TOPK (IC50 = 2.6 nM); selectively inhibits growth of patient-derived AML cells over normal CD34+ cells; inhibits growth of small cell lung, kidney, and ovarian cancer cell lines (IC50s = 0.4-42.6 nM); increases survival in a peritoneal mouse dissemination model of ovarian cancer at 25 and 50 mg/kg; dose-dependently inhibits tumor growth in an A549 mouse xenograft model at 1, 2.5, and 5 mg/kg